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Article

Metabolic selection of glycosylation defects in human cells.

Nature biotechnology - 1 Jun 2001

Yarema K J, Goon S, Bertozzi C R

Abstract excerpt

Changes in glycosylation are often associated with disease progression, but the genetic and metabolic basis of these events is rarely understood in detail at a molecular level. We describe a metabolism-based approach to the selection of mutants in glycoconjugate biosynthesis that provides insight into regulatory mechanisms for oligosaccharide expression and metabolic flux. Unnatural intermediates are used to...

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PMID: 11385460
DOI: 10.1038/89305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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