Biosynthetic glycan modeling reveals metabolic shifts in disease

Abstract excerpt

Glycans are biosynthesized by partly overlapping cascades of enzymatic reactions that can be conceptualized as biosynthetic networks. These networks latently contain reaction rates, substrate specificities, and metabolic states of the underlying cells. Yet extracting this information, across tissues, species, and hundreds of datasets, is challenging with existing methods. Here, we present a new structure-aware alg...

Topics

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• Caco-2 Cells
• Datasets as Topic
• Enzyme Assays
• Glycosylation
• Glycosyltransferases
• Immunoglobulin G
• Mass Spectrometry
• Metabolic Networks and Pathways

Identifiers and source

Literature Corpus work

0d25c392-2bf1-5760-bb82-01f7bdc93e0f

DOI

10.64898/2026.05.21.726792