Article

Discovery of cell-active small molecule inhibitors of UDP-galactose 4’-epimerase

2026-06-19

Abstract excerpt

Glycosylation depends on tightly regulated pools of nucleotide-sugars (NS), yet the mechanisms controlling mammalian NS homeostasis and their downstream effects on glycoprotein biosynthesis remain poorly understood. UDP-galactose 4′-epimerase (GALE) catalyzes the reversible interconversion of UDP-galactose/UDP-glucose and UDP- N -acetylgalactosamine/UDP- N -acetylglucosamine, making it a central regulator of gly...

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Literature Corpus work: f50487c6-be76-5cfa-ab6c-1cfa7fb3cb68
DOI: 10.64898/2026.06.17.733026

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