Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of ITF2 in the transcriptional regulation of melanogenic genes.

The Journal of biological chemistry - 27 Jul 2001

Furumura M, Potterf S B, Toyofuku K, Matsunaga J, Muller J, Hearing V J

Abstract excerpt

In response to agouti signal protein, melanocytes switch from producing eumelanin to pheomelanin concomitant with the down-regulation of melanogenic gene transcription. We previously reported that a ubiquitous basic helix-loop-helix transcription factor, known as ITF2, is up-regulated during this switch, and we now report that treatment of melanocytes with melanocyte-stimulating hormone down-regulates expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanins

Share to Melanocytes

Share to Oligonucleotides, Antisense

Share to Ribonucleases

Share to TCF Transcription Factors

Share to Transcription Factor 4

Source

Identifiers

PMID: 11382753
DOI: 10.1074/jbc.M101626200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of ITF2 in the transcriptional regulation of melanogenic genes.PMID 11382753Read ↗

TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF.Semantic proximity Read ↗

“Transcription physiology” of pigment formation in melanocytes: central role of MITFSemantic proximity Read ↗

MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expressionSemantic proximity Read ↗

MITF: master regulator of melanocyte development and melanoma oncogene.Semantic proximity Read ↗

Beyond MITF: Multiple transcription factors directly regulate the cellular phenotype in melanocytes and melanoma.Semantic proximity Read ↗

Evidence to suggest that expression of MITF induces melanocyte differentiation and haploinsufficiency of MITF causes Waardenburg syndrome type 2A.Semantic proximity Read ↗

TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasisSemantic proximity Read ↗

Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.Semantic proximity Read ↗

A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes.Semantic proximity Read ↗

A direct link between MITF, innate immunity, and hair graying.Semantic proximity Read ↗

Mitf from neural crest to melanoma: signal transduction and transcription in the melanocyte lineage.Semantic proximity Read ↗

GLI2 and M‐MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.