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TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasis

2026-03-11

Abstract excerpt

Transient Receptor Potential Melastatin 2 (TRPM2), a Ca²⁺-permeable cation channel, regulates innate and adaptive immunity and has recently been implicated in vitiligo, an autoimmune pigmentary disorder. However, whether TRPM2 exerts cell-autonomous immunoregulatory functions and how such signaling intersects with pigmentation remain unknown. Here, we reveal an unexpected role for TRPM2 as an intrinsic suppressor...

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Literature Corpus work
12ae3e65-679c-5405-8c91-752cc77185b7
DOI
10.64898/2026.03.09.710699
Open publication

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TRPM2 couples cell-autonomous type-I interferon signaling to pigmentation homeostasisDOI 10.64898/2026.03.09.710699
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