Article
Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.
Scientific reports - 8 Jul 2016
Fehrenbach Sabrina, Novak Daniel, Bernhardt Mathias, Larribere Lionel, Boukamp Petra, Umansky Viktor, Utikal Jochen
Abstract excerpt
Lineage-specific transcription factors determine the cell fate during development. Direct conversion of several cell types into other lineages has been achieved by the overexpression of specific transcription factors. Even cancer cells have been demonstrated to be amenable to transdifferentiation. Here, we identified a distinct set of transcription factors, which are sufficient to transform cells of the...
Topics
- Animals
- Carcinogenesis
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Line, Tumor
- Cell Lineage
- Cell Movement
- Cell Proliferation
- Cell Transdifferentiation
- Chromosome Aberrations
- Cloning, Molecular
- Comparative Genomic Hybridization
- DNA Methylation