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Article

Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage.

Scientific reports - 8 Jul 2016

Fehrenbach Sabrina, Novak Daniel, Bernhardt Mathias, Larribere Lionel, Boukamp Petra, Umansky Viktor, Utikal Jochen

Abstract excerpt

Lineage-specific transcription factors determine the cell fate during development. Direct conversion of several cell types into other lineages has been achieved by the overexpression of specific transcription factors. Even cancer cells have been demonstrated to be amenable to transdifferentiation. Here, we identified a distinct set of transcription factors, which are sufficient to transform cells of the...

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Identifiers

PMID: 27387763
DOI: 10.1038/srep28891
PMCID: PMC4937495

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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