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Article

A direct link between MITF, innate immunity, and hair graying.

PLoS biology - 1 May 2018

Harris Melissa L, Fufa Temesgen D, Palmer Joseph W, Joshi Sandeep S, Larson Denise M, Incao Arturo, Gildea Derek E, Trivedi Niraj S, Lee Autumne N, Day Chi-Ping, Michael Helen T, Hornyak Thomas J, Merlino Glenn, Pavan William J

Abstract excerpt

Melanocyte stem cells (McSCs) and mouse models of hair graying serve as useful systems to uncover mechanisms involved in stem cell self-renewal and the maintenance of regenerating tissues. Interested in assessing genetic variants that influence McSC maintenance, we found previously that heterozygosity for the melanogenesis associated transcription factor, Mitf, exacerbates McSC differentiation and hair graying in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon Type I

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Source

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Identifiers

PMID: 29723194
DOI: 10.1371/journal.pbio.2003648
PMCID: PMC5933715

Genes

MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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