Article
Mutation-tolerant protein identification by mass spectrometry.
Journal of computational biology : a journal of computational molecular cell biology - 1 Jan 2000
Pevzner P A, Dancík V, Tang C L
Abstract excerpt
Database search in tandem mass spectrometry is a powerful tool for protein identification. High-throughput spectral acquisition raises the problem of dealing with genetic variation and peptide modifications within a population of related proteins. A method that cross-correlates and clusters related spectra in large collections of uncharacterized spectra (i.e., from normal and diseased individuals) would be very...
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