Article
TagRecon: high-throughput mutation identification through sequence tagging.
Journal of proteome research - 5 Apr 2010
Dasari Surendra, Chambers Matthew C, Slebos Robbert J, Zimmerman Lisa J, Ham Amy-Joan L, Tabb David L
Abstract excerpt
Shotgun proteomics produces collections of tandem mass spectra that contain all the data needed to identify mutated peptides from clinical samples. Identifying these sequence variations, however, has not been feasible with conventional database search strategies, which require exact matches between observed and expected sequences. Searching for mutations as mass shifts on specified residues through database...
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