Article
Molecular basis for treatment of mitochondrial myopathies.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Jan 2000
Taylor R W, Wardell T M, Lightowlers R N, Turnbull D M
Abstract excerpt
Mitochondrial DNA (mtDNA) is the only autonomously replicating source of DNA outside the nucleus. The mitochondrial genome encodes thirteen essential polypeptides of the mitochondrial respiratory chain. Defects of the mitochondrial genome can cause severe neurological and multi-systemic disorders. In many patients there is a mixture of mutated and wild-type mtDNA in the same cell (a situation termed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.