Article
Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation.
Scientific reports - 6 Sept 2017
Chang Jui-Chih, Hoel Fredrik, Liu Ko-Hung, Wei Yau-Huei, Cheng Fu-Chou, Kuo Shou-Jen, Tronstad Karl Johan, Liu Chin-San
Abstract excerpt
The cell penetrating peptide, Pep-1, has been shown to facilitate cellular uptake of foreign mitochondria but further research is required to evaluate the use of Pep-1-mediated mitochondrial delivery (PMD) in treating mitochondrial defects. Presently, we sought to determine whether mitochondrial transplantation rescue mitochondrial function in a cybrid cell model of mitochondrial myopathy, encephalopathy, lactic...
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