Article
Strategies for treating disorders of the mitochondrial genome.
Biochimica et biophysica acta - 6 Dec 2004
Smith Paul M, Ross Günther F, Taylor Robert W, Turnbull Douglass M, Lightowlers Robert N
Abstract excerpt
Defects of the mitochondrial genome are a significant cause of disease. Patients suffer from a wide variety of clinical presentations, ranging from fatal infantile disease to mild muscle weakness. Most disorders, however, are characterized by inexorable progression. As mutations often cause defects in several components of the complexes that couple oxidative phosphorylation, this terminal state of oxidative...
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