Article
In-vitro genetic modification of mitochondrial function.
Human reproduction (Oxford, England) - 1 Jul 2000
Taylor R W, Chinnery P F, Turnbull D M, Lightowlers R N
Abstract excerpt
Defects of mitochondrial (mt) DNA cause a diverse group of incurable, progressive diseases that often lead to severe disability and premature death. Most patients with pathogenic mtDNA defects have a mixture of mutant and wild-type mtDNA (heteroplasmy), and the clinical defect is only expressed when the percentage of mutant mtDNA exceeds a critical threshold. Since mtDNA is continually replicating and being...
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