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A Mitochondrial Encoded Messenger at the Nucleus

13 Aug 2018

Abstract excerpt

Mitochondria–nucleus (mitonuclear) retrograde signaling via nuclear import of otherwise mitochondrial targeted factors occurs during mitochondrial unfolded protein response (UPRmt), a mechanism that counters mitochondrial and cellular stresses. Other than nuclear encoded proteins, mitochondrial DNA (mtDNA)-encoded peptides, such as humanin, are known to have important pro-survival and metabolic regulatory...

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PMID: 30104535
DOI: 10.3390/cells7080105

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