Article
Functional genetic analysis of the mammalian mitochondrial DNA encoded peptides: a mutagenesis approach.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Bayona-Bafaluy María Pilar, Movilla Nieves, Pérez-Martos Acisclo, Fernández-Silva Patricio, Enriquez José Antonio
Abstract excerpt
Animal mitochondria are refractory to transformation. This fact has hampered the study of the oxidative phosphorylation system biogenesis by genetic manipulation of the mitochondrial DNA (mtDNA). In humans, a larger variety of mutants have been obtained from patients with mitochondrial diseases, but still we lack a great portion of the range of potential mutants and there is a major obstacle: Animal models cannot...
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