Article
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1
29 May 2001
Abstract excerpt
A mammalian A-type cyclin, cyclin A1, is highly expressed in testes of both human and mouse and targeted mutagenesis in the mouse has revealed the unique requirement for cyclin A1 in the progression of male germ cells through the meiotic cell cycle. While very low levels of cyclin A1 have been reported in the human hematopoietic system and brain, the sites of elevated levels of expression of human cyclin A1 were...
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