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Article

Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma.

Blood - 15 Nov 2005

Kundu Mondira, Compton Sheila, Garrett-Beal Lisa, Stacy Terryl, Starost Matthew F, Eckhaus Michael, Speck Nancy A, Liu P Paul

Abstract excerpt

Chromosomal rearrangements affecting RUNX1 and CBFB are common in acute leukemias. These mutations result in the expression of fusion proteins that act dominant-negatively to suppress the normal function of the Runt-related transcription factor 1 (RUNX)/core binding factor beta (CBFbeta) complexes. In addition, loss-of-function mutations in Runt-related transcription factor 1 (RUNX1) have been identified in...

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Share to Chromosome Aberrations
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Leukemia, Myeloid, Acute

Share to Mice, Mutant Strains

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed Open full text

Identifiers

PMID: 16051740
DOI: 10.1182/blood-2005-04-1447
PMCID: PMC1459843

Genes

RUNX1
CBFB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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