Cyclin A1 is required for meiosis in the male mouse.

doi:10.1038/3855

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Article

Cyclin A1 is required for meiosis in the male mouse.

Nature genetics - 1 Dec 1998

Liu D, Matzuk M M, Sung W K, Guo Q, Wang P, Wolgemuth D J

Abstract excerpt

The mammalian A-type cyclin family consists of two members, cyclin A1 (encoded by Ccna1) and cyclin A2 (encoded by Ccna2). Cyclin A2 promotes both G1/S and G2/M transitions, and targeted deletion of Ccna2 in mouse is embryonic lethal3. Cyclin A1 is expressed in mice exclusively in the germ cell l...

Topics

Animals
CDC2-CDC28 Kinases
Cyclin A
Cyclin A1
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinases
Enzyme Activation
Female
Male
Meiosis
Mice
Mice, Knockout
Phenotype
Protein Serine-Threonine Kinases
Spermatogenesis

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