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Article

Cyclin A1 is required for meiosis in the male mouse.

Nature genetics - 1 Dec 1998

Liu D, Matzuk M M, Sung W K, Guo Q, Wang P, Wolgemuth D J

Abstract excerpt

The mammalian A-type cyclin family consists of two members, cyclin A1 (encoded by Ccna1) and cyclin A2 (encoded by Ccna2). Cyclin A2 promotes both G1/S and G2/M transitions, and targeted deletion of Ccna2 in mouse is embryonic lethal3. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and is expressed in humans at highest levels in the testis and certain myeloid leukaemia cells. To investigate...

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Identifiers

PMID: 9843212
DOI: 10.1038/3855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Cyclin A1 is required for meiosis in the male mouse.PMID 9843212Read ↗

The A‐type cyclins and the meiotic cell cycle in mammalian male germ cellsSemantic proximity Read ↗

Role of cyclins in controlling progression of mammalian spermatogenesisSemantic proximity Read ↗

A distinct cyclin A is expressed in germ cells in the mouseSemantic proximity Read ↗

Cyclin A2 is essential for mouse gonocyte maturation.Semantic proximity Read ↗

Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero.Semantic proximity Read ↗

Meiosis I arrest abnormalities lead to severe oligozoospermia in meiosis 1 arresting protein (M1ap)-deficient mice.Semantic proximity Read ↗

Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male MeiosisSemantic proximity Read ↗

Regulating mitosis and meiosis in the male germ line: critical functions for cyclinsSemantic proximity Read ↗

MARF1 regulates essential oogenic processes in mice.Semantic proximity Read ↗

Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes.Semantic proximity Read ↗

Proteomic analysis of male 4C germ cell proteins involved in mouse meiosisSemantic proximity Read ↗

CDC6 requirement for spindle formation during maturation of mouse oocytes.Semantic proximity Read ↗

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