Article
Otx1 and Otx2 activities are required for the normal development of the mouse inner ear.
Development (Cambridge, England) - 1 Jun 1999
Morsli H, Tuorto F, Choo D, Postiglione M P, Simeone A, Wu D K
Abstract excerpt
The Otx1 and Otx2 genes are two murine orthologues of the Orthodenticle (Otd) gene in Drosophila. In the developing mouse embryo, both Otx genes are expressed in the rostral head region and in certain sense organs such as the inner ear. Previous studies have shown that mice lacking Otx1 display abnormal patterning of the brain, whereas embryos lacking Otx2 develop without heads. In this study, we examined, at...
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