Article
Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.
Development (Cambridge, England) - 1 May 1998
Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring W J, Finkelstein R, Furukubo-Tokunaga K, Reichert H
Abstract excerpt
Members of the orthodenticle gene family are essential for embryonic brain development in animals as diverse as insects and mammals. In Drosophila, mutational inactivation of the orthodenticle gene results in deletions in anterior parts of the embryonic brain and in defects in the ventral nerve c...
Topics
- Animals
- Animals, Genetically Modified
- Brain
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Gene Expression
- Genes, Homeobox
- Genes, Insect
- Homeodomain Proteins
- Hot Temperature
- Humans
- Morphogenesis
- Mutation
- Nerve Tissue Proteins