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Article

Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.

Development (Cambridge, England) - 1 May 1998

Leuzinger S, Hirth F, Gerlich D, Acampora D, Simeone A, Gehring W J, Finkelstein R, Furukubo-Tokunaga K, Reichert H

Abstract excerpt

Members of the orthodenticle gene family are essential for embryonic brain development in animals as diverse as insects and mammals. In Drosophila, mutational inactivation of the orthodenticle gene results in deletions in anterior parts of the embryonic brain and in defects in the ventral nerve cord. In the mouse, targeted elimination of the homologous Otx2 or Otx1 genes causes defects in forebrain and/or...

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Source

Identifiers

PMID: 9521908
DOI: 10.1242/dev.125.9.1703

Genes

OTX1
OTX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.PMID 9521908Read ↗

Otx genes in the development and evolution of the vertebrate brain.Semantic proximity Read ↗

Otx1 function overlaps with Otx2 in development of mouse forebrain and midbrain.Semantic proximity Read ↗

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.Semantic proximity Read ↗

Differential transcriptional control as the major molecular event in generating Otx1-/- and Otx2-/- divergent phenotypes.Semantic proximity Read ↗

Cooperation between Otx1 and Otx2 genes in developmental patterning of rostral brain.Semantic proximity Read ↗

The role of Otx and Otp genes in brain development.Semantic proximity Read ↗

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.Semantic proximity Read ↗

Functional equivalency between Otx2 and Otx1 in development of the rostral head.Semantic proximity Read ↗

Cross-phylum regulatory potential of the ascidian Otx gene in brain development in Drosophila melanogaster.Semantic proximity Read ↗

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation.Semantic proximity Read ↗

OTX1 compensates for OTX2 requirement in regionalisation of anterior neuroectoderm.Semantic proximity Read ↗

Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain.Semantic proximity Read ↗

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