Article
Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.
Developmental biology - 15 Mar 2008
Ranade Swati S, Yang-Zhou Donghui, Kong Sek Won, McDonald Elizabeth C, Cook Tiffany A, Pignoni Francesca
Abstract excerpt
Homeobox transcription factors of the vertebrate CRX/OTX family play critical roles in photoreceptor neurons, the rostral brain and circadian processes. In mouse, the three related proteins, CRX, OTX1, and OTX2, fulfill these functions. In Drosophila, the single founding member of this gene family, called orthodenticle (otd), is required during embryonic brain and photoreceptor neuron development. We have used...
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