Article
The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.
Genes & development - 1 Sept 1990
Finkelstein R, Smouse D, Capaci T M, Spradling A C, Perrimon N
Abstract excerpt
The orthodenticle (otd) locus of Drosophila is required for embryonic development, and null mutations of otd cause defects in head development and segmental patterning. We show here that otd is necessary for the formation of the embryonic central nervous system (CNS). otd mutations result in the formation of an abnormal neuropil and in the disappearance of identified neurons associated with the midline of the...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System
- Cloning, Molecular
- Drosophila
- Gene Expression Regulation
- Genes, Homeobox
- Molecular Sequence Data
- Mutation