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Article

Mutation of aspartate 82 of the human C5a receptor abolishes the secretory response to human C5a in transfected rat basophilic leukemia cells.

European journal of immunology - 1 Nov 1994

Monk P N, Pease J E, Marland G, Barker M D

Abstract excerpt

C5a is a potent chemoattractant for monocytes, neutrophils and other leukocytes. The receptor for human C5a is a member of the rhodopsin superfamily of G protein-coupled receptors and contains an aspartate residue (Asp82) within the putative second transmembrane domain conserved in all other G pr...

Topics

Animals
Aspartic Acid
Calcium
Complement C5a
GTP-Binding Proteins
Humans
Leukemia, Basophilic, Acute
Mutation
Rats
Receptor, Anaphylatoxin C5a
Receptors, Complement
Serotonin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Structure-Activity Relationship

Transfection

Tumor Cells, Cultured

Source

Identifiers

PMID: 7957584
DOI: 10.1002/eji.1830241152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7957584-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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