Article
Endogenous mutagenesis and cancer.
Mutation research - 30 Nov 2002
Davidson John F, Guo Haiwei H, Loeb Lawrence A
Abstract excerpt
Mutations in DNA accrue relentlessly, largely via stochastic processes. Random changes accumulate, eventually disabling genetic components which result in the formation of the cancer phenotype. Given the infrequency of measured nucleotide changes and the requirement for several mutations to occur in the same cell, it has been postulated that the rate of mutation must become elevated early in the course of...
Topics
- Base Sequence
- Chromosome Aberrations
- Humans
- Mutation
- Neoplasms
- Phenotype