Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.

Diabetologia - 1 Aug 2007

Sarkar S A, Gunter J, Bouchard R, Reusch J E-B, Wiseman A, Gill R G, Hutton J C, Pugazhenthi S

Abstract excerpt

AIMS/HYPOTHESIS: Transplantation of islets is a viable option for the treatment of diabetes. A significant proportion of islets is lost during isolation, storage and after transplantation as a result of apoptosis. cAMP response element binding protein (CREB) is an important cell survival factor. The aim of the present study was to determine whether preservation of CREB function is needed for survival of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cadaver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caspase 9

Share to Caspases

Share to Cyclic AMP Response Element-Binding Protein

Share to In Situ Nick-End Labeling

Share to Intercellular Signaling Peptides and Proteins

Share to Islets of Langerhans

Source

Identifiers

PMID: 17593347
DOI: 10.1007/s00125-007-0707-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Dominant negative mutant forms of the cAMP response element binding protein induce apoptosis and decrease the anti-apoptotic action of growth factors in human islets.PMID 17593347Read ↗

Distinct In Vivo Roles of Caspase-8 in β-Cells in Physiological and Diabetes ModelsSemantic proximity Read ↗

CYTOPROTECTION OF PANCREATIC ISLETS BEFORE AND SOON AFTER TRANSPLANTATION BY GENE TRANSFER OF THE ANTI-APOPTOTIC Bcl-2 GENE1Semantic proximity Read ↗

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survivalSemantic proximity Read ↗

In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.Semantic proximity Read ↗

Apoptosis in hypoxic human pancreatic islets correlates with HIF‐1α expressionSemantic proximity Read ↗

c-Jun regulates postpartum β-cell apoptosis and survival downstream of prolactin signalingSemantic proximity Read ↗

Role for Activating Transcription Factor 3 in Stress-Induced β-Cell ApoptosisSemantic proximity Read ↗

The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human isletsSemantic proximity Read ↗

Proximal cyclic AMP response element is essential for exendin-4 induction of rat EGR-1 gene.Semantic proximity Read ↗

Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.