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Article

Apoptosis in hypoxic human pancreatic islets correlates with HIF‐1α expression

26 Mar 2002

Abstract excerpt

To become insulin independent, patients with type 1 diabetes mellitus require transplantation of at least two donor pancreata because of massive beta-cell loss in the early post-transplantation period. Many studies describing the introduction of new immunosuppressive protocols have shown that this loss is due to not only immunological events but also nonimmunological factors. To test to what extent hypoxia may...

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PMID: 11923216
DOI: 10.1096/fj.01-0403fje

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