Article
Crystal structures of nucleotide exchange intermediates in the eEF1A-eEF1Balpha complex.
Nature structural biology - 1 Jun 2001
Andersen G R, Valente L, Pedersen L, Kinzy T G, Nyborg J
Abstract excerpt
In the elongation cycle of protein biosynthesis, the nucleotide exchange factor eEF1Balpha catalyzes the exchange of GDP bound to the G-protein, eEF1A, for GTP. To obtain more information about the recently solved eEF1A-eEF1Balpha structure, we determined the structures of the eEF1A-eEF1Balpha-GDP-Mg2+, eEF1A-eEF1Balpha-GDP and eEF1A-eEF1Balpha-GDPNP complexes at 3.0, 2.4 and 2.05 A resolution, respectively....
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