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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A

3 Feb 2025

Abstract excerpt

Eukaryotic translation elongation factor 1A (eEF1A) is a highly abundant, multi-domain GTPase. Post-translational steps essential for eEF1A biogenesis are carried out by bespoke chaperones but co-translational mechanisms tailored to eEF1A folding remain unexplored. Here, we use AlphaPulldown to identify Ypl225w (also known as Chp1, Chaperone 1 for eEF1A) as a conserved yeast protein predicted to stabilize the...

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PMID: 39900909
DOI: 10.1038/s41467-025-56489-3

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