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Article

Guanine nucleotide exchange factor independence of the G-protein eEF1A through novel mutant forms and biochemical properties.

The Journal of biological chemistry - 22 Aug 2008

Ozturk Sedide B, Kinzy Terri Goss

Abstract excerpt

Most G-proteins require a guanine nucleotide exchange factor (GEF) to regulate a variety of critical cellular processes. Interestingly, a small number of G-proteins switch between the active and inactive forms without a GEF. Translation elongation factor 1A (eEF1A) normally requires the GEF eEF1Balpha to accelerate nucleotide dissociation. However, several mutant forms of eEF1A are functional independent of this...

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Identifiers

PMID: 18562321
DOI: 10.1074/jbc.M801095200
PMCID: PMC2517005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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