Article
Synonymous codon bias is not caused by mutation bias in G+C-rich genes in humans.
Molecular biology and evolution - 1 Jun 2001
Smith N G, Eyre-Walker A
Abstract excerpt
It is has been suggested that synonymous codon bias is a consequence of mutation bias in mammals. We tested this hypothesis in humans using single-nucleotide polymorphism data. We found a pattern of polymorphism which was inconsistent with the mutation bias hypothesis in G+C-rich genes. However, the data were consistent with the action of natural selection or biased gene conversion. Similar patterns of...
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