An analysis of codon usage in mammals: selection or mutation bias?

Abstract excerpt

A new statistical test has been developed to detect selection on silent sites. This test compares the codon usage within a gene and thus does not require knowledge of which genes are under the greatest selection, that there exist common trends in codon usage across genes, or that genes have the same mutation pattern. It also controls for mutational biases that might be introduced by the adjacent bases. The test...

Topics

• Animals
• Base Composition
• Codon
• Humans
• Mammals
• Mice
• Models, Genetic
• Models, Statistical
• Mutation
• Proteins
• Rats
• Reading Frames
• Selection, Genetic