Article
Hsp90 levels affect telomere length in yeast.
Molecular genetics and genomics : MGG - 1 Mar 2001
Grandin N, Charbonneau M
Abstract excerpt
Cdc13 is a Saccharomyces cerevisiae protein that binds to telomeric single-stranded DNA and regulates telomerase activity. Stnl has been shown by two-hybrid analysis to form a physical complex with Cdc13. Temperature-sensitive mutations in CDC13 and STN1, which are both essential genes, activate a DNA damage-dependent checkpoint which is the cause of the arrest seen in the mutant strains. The stn1-13 mutation...
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