Article
ABCB1 gene polymorphisms are not associated with treatment outcome in elderly acute myeloid leukemia patients.
Clinical pharmacology and therapeutics - 1 Nov 2006
van der Holt Bronno, Van den Heuvel-Eibrink Marry M, Van Schaik Ron H N, van der Heiden Ilse P, Wiemer Erik A C, Vossebeld Paula J M, Löwenberg Bob, Sonneveld Pieter
Abstract excerpt
OBJECTIVES: The classical multidrug resistance (MDR) gene MDR1 (ABCB1) encodes for the drug efflux pump P-glycoprotein (P-gp). P-gp expression is an adverse prognostic factor for treatment outcome in acute myeloid leukemia (AML) and is more frequently observed in older patients. Single-nucleotide polymorphisms of the ABCB1 gene, C1236T, G2677T, and C3435T, have been associated with altered drug metabolism and...
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