Article
A T3587G germ-line mutation of the MDR1 gene encodes a nonfunctional P-glycoprotein.
Molecular cancer therapeutics - 1 Apr 2006
Mutoh Kazuyoshi, Mitsuhashi Junko, Kimura Yasuhisa, Tsukahara Satomi, Ishikawa Etsuko, Sai Kimie, Ozawa Shogo, Sawada Jun-ichi, Ueda Kazumitsu, Katayama Kazuhiro, Sugimoto Yoshikazu
Abstract excerpt
The human multidrug resistance gene 1 (MDR1) encodes a plasma membrane P-glycoprotein (P-gp) that functions as an efflux pump for various structurally unrelated anticancer agents. We have identified two nonsynonymous germ-line mutations of the MDR1 gene, C3583T MDR1 and T3587G MDR1, in peripheral blood cell samples from Japanese cancer patients. Two patients carried the C3583T MDR1 allele that encodes H1195Y...
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