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Deep-sequencing approach for minimal residual disease detection in acute lymphoblastic leukemia

18 Oct 2012

Abstract excerpt

The persistence of minimal residual disease (MRD) during therapy is the strongest adverse prognostic factor in acute lymphoblastic leukemia (ALL). We developed a high-throughput sequencing method that universally amplifies antigen-receptor gene segments and identifies all clonal gene rearrangements (ie, leukemia-specific sequences) at diagnosis, allowing monitoring of disease progression and clonal evolution...

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PMID: 23074282
DOI: 10.1182/blood-2012-07-444042

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