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Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

1 May 2001

Abstract excerpt

A "spindle assembly" checkpoint has been described that arrests cells in G1 following inappropriate exit from mitosis in the presence of microtubule inhibitors. We have here addressed the question of whether the resulting tetraploid state itself, rather than failure of spindle function or induction of spindle damage, acts as a checkpoint to arrest cells in G1. Dihydrocytochalasin B induces cleavage failure in...

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PMID: 11359924
DOI: 10.1091/mbc.12.5.1315

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