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Article

Failure of cell cleavage induces senescence in tetraploid primary cells

21 Aug 2014

Abstract excerpt

Tetraploidy can arise from various mitotic or cleavage defects in mammalian cells, and inheritance of multiple centrosomes induces aneuploidy when tetraploid cells continue to cycle. Arrest of the tetraploid cell cycle is therefore potentially a critical cellular control. We report here that primary rat embryo fibroblasts (REF52) and human foreskin fibroblasts become senescent in tetraploid G1 after drug- or...

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PMID: 25143403
DOI: 10.1091/mbc.e14-03-0844

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