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Article

The requirement of p53 for maintaining chromosomal stability during tetraploidization

24 Nov 2010

Abstract excerpt

Tetraploidization is believed to promote genome instability and tumorigenesis. Whether tetraploids per se are intrinsically unstable and transforming remain incompletely understood. In this report, tetraploidization was induced with cell fusion using mouse fibroblasts. Due to the unequal segregation of chromosomes during multipolar mitosis, the majority of cells were eliminated by p53-dependent mechanisms after...

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PMID: 21317454
DOI: 10.18632/oncotarget.193

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