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p53 Dependent Centrosome Clustering Prevents Multipolar Mitosis in Tetraploid Cells

4 Nov 2011

Abstract excerpt

BACKGROUND: p53 abnormality and aneuploidy often coexist in human tumors, and tetraploidy is considered as an intermediate between normal diploidy and aneuploidy. The purpose of this study was to investigate whether and how p53 influences the transformation from tetraploidy to aneuploidy. PRINCIPAL FINDINGS: Live cell imaging was performed to determine the fates and mitotic behaviors of several human and mouse...

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PMID: 22076149
DOI: 10.1371/journal.pone.0027304

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