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Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

15 Feb 2005

Abstract excerpt

BACKGROUND: Mammalian cells have been reported to have a p53-dependent tetraploidy checkpoint that blocks cell cycle progression in G1 in response to failure of cell division. In most cases where the tetraploidy checkpoint has been observed cell division was perturbed by anti-cytoskeleton drug treatments. However, other evidence argues against the existence of a tetraploidy checkpoint. Cells that have failed to...

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PMID: 15713235
DOI: 10.1186/1471-2121-6-6

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