Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase.

Molecular and cellular biology - 1 Jun 2001

Lu Z, Jiang G, Blume-Jensen P, Hunter T

Abstract excerpt

Upregulated epidermal growth factor (EGF) receptor (EGFR) expression and EGFR-induced signaling have been correlated with progression to invasion and metastasis in a wide variety of carcinomas, but the mechanism behind this is not well understood. We show here that, in various human carcinoma cells that overexpress EGFR, EGF treatment induced rapid tyrosine dephosphorylation of focal adhesion kinase (FAK)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Alu Elements
Share to Epidermal Growth Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 1

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Mice, Nude

Share to Paxillin

Share to Retinoblastoma-Like Protein p130

Source

Open in PubMed Open full text

Identifiers

PMID: 11359909
DOI: 10.1128/MCB.21.12.4016-4031.2001
PMCID: PMC87064

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase.PMID 11359909Read ↗

Control of motile and invasive cell phenotypes by focal adhesion kinase.Semantic proximity Read ↗

Focal adhesion kinase (FAK): emerging target for drug-resistant malignant tumorsSemantic proximity Read ↗

Focal adhesion kinase and cancer.Semantic proximity Read ↗

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.Semantic proximity Read ↗

Understanding the Roles of FAK in CancerSemantic proximity Read ↗

FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.Semantic proximity Read ↗

Clinical significance of FAK expression in human neoplasia.Semantic proximity Read ↗

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.Semantic proximity Read ↗

FAK regulates biological processes important for the pathogenesis of cancer.Semantic proximity Read ↗

Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src.Semantic proximity Read ↗

Focal Adhesion Kinase: Insight into Molecular Roles and Functions in Hepatocellular CarcinomaSemantic proximity Read ↗

FAK signaling in human cancer as a target for therapeuticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.