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Article

The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide element.

PloS one - 30 Dec 2010

Azzi Sandy, Parissi Vincent, Maroun Richard G, Eid Pierre, Mauffret Olivier, Fermandjian Serge

Abstract excerpt

Monoclonal antibodies (MAbas) constitute remarkable tools to analyze the relationship between the structure and the function of a protein. By immunizing a mouse with a 29mer peptide (K159) formed by residues 147 to 175 of the HIV-1 integrase (IN), we obtained a monoclonal antibody (MAba4) recognizing an epitope lying in the N-terminal portion of K159 (residues 147-166 of IN). The boundaries of the epitope were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21209864
DOI: 10.1371/journal.pone.0016001
PMCID: PMC3012736

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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