Article
Spermiogenesis deficiency in mice lacking the Trf2 gene.
Science (New York, N.Y.) - 11 May 2001
Zhang D, Penttila T L, Morris P L, Teichmann M, Roeder R G
Abstract excerpt
The discovery of TATA-binding protein-related factors (TRFs) has suggested alternative mechanisms for gene-specific transcriptional regulation and raised interest in their biological functions. In contrast to recent observations of an embryonic lethal phenotype for TRF2 inactivation in Caenorhabditis elegans and Xenopus laevis, we found that Trf2-deficient mice are viable. However, Trf2-/- mice are sterile...
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