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Article

Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis.

Development (Cambridge, England) - 1 Jul 2003

Ayyar Savita, Jiang Jianqiao, Collu Anna, White-Cooper Helen, White Robert A H

Abstract excerpt

We have investigated the role of TGIF, a TALE-class homeodomain transcription factor, in Drosophila development. In vertebrates, TGIF has been implicated, by in vitro analysis, in several pathways, most notably as a repressor modulating the response to TGFbeta signalling. Human TGIF has been associated with the developmental disorder holoprosencephaly. Drosophila TGIF is represented by the products of two...

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Identifiers

PMID: 12756169
DOI: 10.1242/dev.00513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis.PMID 12756169Read ↗

Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis.Semantic proximity Read ↗

Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Semantic proximity Read ↗

Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early.Semantic proximity Read ↗

Differential roles of TGIF family genes in mammalian reproductionSemantic proximity Read ↗

Spermiogenesis deficiency in mice lacking the Trf2 gene.Semantic proximity Read ↗

TGIF2 Interacts with Histone Deacetylase 1 and Represses TranscriptionSemantic proximity Read ↗

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.Semantic proximity Read ↗

Developmental regulation of transcription by a tissue-specific TAF homolog.Semantic proximity Read ↗

A germline PAF1 paralog complex ensures cell type-specific gene expressionSemantic proximity Read ↗

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.Semantic proximity Read ↗

Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouseSemantic proximity Read ↗

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.Semantic proximity Read ↗

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