Article
Two isoforms of Drosophila TRF2 are involved in embryonic development, premeiotic chromatin condensation, and proper differentiation of germ cells of both sexes.
Molecular and cellular biology - 1 Oct 2006
Kopytova Daria V, Krasnov Aleksey N, Kopantceva Marina R, Nabirochkina Elena N, Nikolenko Julia V, Maksimenko Oksana, Kurshakova Maria M, Lebedeva Lubov A, Yerokhin Maksim M, Simonova Olga B, Korochkin Leonid I, Tora Laszlo, Georgiev Pavel G, Georgieva Sofia G
Abstract excerpt
The Drosophila TATA box-binding protein (TBP)-related factor 2 (TRF2 or TLF) was shown to control a subset of genes different from that controlled by TBP. Here, we have investigated the structure and functions of the trf2 gene. We demonstrate that it encodes two protein isoforms: the previously described 75-kDa TRF2 and a newly identified 175-kDa version in which the same sequence is preceded by a long N-terminal...
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