Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.

Seminars in hematology - 1 Oct 1997

Reed J C

Abstract excerpt

Nearly all anticancer drugs presently available to clinicians kill tumor cells by activating an endogenous biochemical pathway for cell suicide, known as programmed cell death or apoptosis. However, many malignant cells develop defects in the regulation of genes that control apoptosis, rendering them resistant to the induction of apoptosis by a wide variety of stimuli, including chemotherapeutic drugs and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Drug Resistance, Neoplasm
Share to Lymphoma, Non-Hodgkin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Proto-Oncogene Proteins c-bcl-2

Share to Signal Transduction

Source

Identifiers

PMID: 9408956

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.PMID 9408956Read ↗

BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.Semantic proximity Read ↗

BCL-2 family proteins: Regulators of cell death involved in the pathogenesis of cancer and resistance to therapySemantic proximity Read ↗

Targeting the B-Cell Lymphoma/Leukemia 2 Family in CancerSemantic proximity Read ↗

Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small moleculesSemantic proximity Read ↗

The Bcl-2 family: roles in cell survival and oncogenesisSemantic proximity Read ↗

Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?Semantic proximity Read ↗

B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer TherapySemantic proximity Read ↗

The role of the Bcl-2 protein family in cancer.Semantic proximity Read ↗

Targeting Bcl-2 Family Proteins: What, Where, When?Semantic proximity Read ↗

<i>BCL2</i> Family of Apoptosis-Related Genes: Functions and Clinical Implications in CancerSemantic proximity Read ↗

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic ContextSemantic proximity Read ↗

REGULATION OF CLINICAL CHEMORESISTANCE BY bcl‐2 AND BAX ONCOPROTEINS IN B‐CELL CHRONIC LYMPHOCYTIC LEUKAEMIASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.