Article
Allelic IGF2R repression does not correlate with expression of antisense RNA in human extraembryonic tissues.
Genomics - 1 May 2001
Oudejans C B, Westerman B, Wouters D, Gooyer S, Leegwater P A, van Wijk I J, Sleutels F
Abstract excerpt
In the mouse, expression of an antisense Igf2r RNA (Air) is correlated with Igf2r repression on the paternal allele. One of the possible models for Igf2r repression could be through promoter competition or through the action of the Air RNA, in, e.g., transcriptional interference or repressor binding. These models predict the conservation of AIR RNA in human samples with monoallelic IGF2R expression and the...
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