Article
Absence of an obvious molecular imprinting mechanism in a human fetus with monoallelic IGF2R expression.
Biochemical and biophysical research communications - 7 Apr 1998
Riesewijk A M, Xu Y Q, Schepens M T, Mariman E M, Polychronakos C, Ropers H H, Kalscheuer V M
Abstract excerpt
We have previously shown that, in contrast to its murine homologue, the human IGF2R gene is not imprinted. However, in a small number of individuals, partial or complete repression of the paternal allele has been observed and it has been speculated that in man, IGF2R imprinting is a polymorphic trait. We have confirmed monoallelic IGF2R expression in one fetus and investigated whether genomic imprinting was...
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