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Article

Conservation of a maternal-specific methylation signal at the human IGF2R locus.

Human molecular genetics - 1 Oct 1995

Smrzka O W, Faé I, Stöger R, Kurzbauer R, Fischer G F, Henn T, Weith A, Barlow D P

Abstract excerpt

The human IGF2R gene has been reported to be either biallelically or very rarely monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We describe here an analysis of the 5' portion of the human IGF2R gene and show that it contains a maternally methylated CpG island in the second intron. A similar maternally methylated intronic element has been proposed to be the imprinting box for...

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Identifiers

PMID: 8595419
DOI: 10.1093/hmg/4.10.1945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Conservation of a maternal-specific methylation signal at the human IGF2R locus.PMID 8595419Read ↗

Maternal-specific methylation of the human IGF2R gene is not accompanied by allele-specific transcription.Semantic proximity Read ↗

Absence of an obvious molecular imprinting mechanism in a human fetus with monoallelic IGF2R expression.Semantic proximity Read ↗

Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signalSemantic proximity Read ↗

Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.Semantic proximity Read ↗

The insulin-like growth factor type-2 receptor gene is imprinted in the mouse but not in humans.Semantic proximity Read ↗

Imprinting of the mouse Igf2r gene depends on an intronic CpG island.Semantic proximity Read ↗

RNA-FISH to analyze allele-specific expression.Semantic proximity Read ↗

Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting.Semantic proximity Read ↗

Tissue-specific imprinting of the mouse insulin-like growth factor II receptor gene correlates with differential allele-specific DNA methylation.Semantic proximity Read ↗

The MAS proto-oncogene is not imprinted in humans.Semantic proximity Read ↗

IGF2 is parentally imprinted during human embryogenesis and in the Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Imprinted expression of the Igf2r gene depends on an intronic CpG islandSemantic proximity Read ↗

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