Article
Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jul 2018
Dahl-Halvarsson Martin, Olive Montse, Pokrzywa Malgorzata, Ejeskär Katarina, Palmer Ruth H, Uv Anne Elisabeth, Tajsharghi Homa
Abstract excerpt
Myosin is a molecular motor indispensable for body movement and heart contractility. Apart from pure cardiomyopathy, mutations in MYH7 encoding slow/β-cardiac myosin heavy chain also cause skeletal muscle disease with or without cardiac involvement. Mutations within the α-helical rod domain of MYH7 are mainly associated with Laing distal myopathy. To investigate the mechanisms underlying the pathology of the...
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